Clinical Genomics Scientist, Oncology

Ph.D. in Human Genetics, M.S. in Genetic Counseling, or related field. 2+ years of experience in somatic variant interpretation based on ACMG/AMP guidelines in a clinical setting (or alternative germline/somatic combination). Hands-on experience with human mutation databases (COSMIC, ClinVar, OncoKB), functional annotation sources (dbSNP), and genome browsers (UCSC). Familiarity with IGV and BAM file analysis, and willingness to learn basic bioinformatics tools. Knowledge of cancer somatic mutation and signaling pathways. Exceptional attention to detail and strong organizational skills. Excellent communication skills and ability to work collaboratively. Operationally-defined flexible schedule, including weekends.

Perform somatic variant interpretation and data review, classifying variants and matching treatments. Draft clinical reports for each requisition using in-house reporting API. Develop and modify somatic interpretation SOPs in accordance with guidelines and literature. Contribute to curation of gene-level content. Serve as a subject matter expert in molecular tumor boards. Assist R&D team with somatic oncology projects, providing expertise on variant interpretation and biological pathways.