Spyre Therapeutics

Spyre Therapeutics is a biotechnology business that is developing a strong pipeline of antibody therapies.

1-50 employees

Founded 2023

$180M post ipo equity

Biotechnology

Public Company

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Biotechnology Therapeutics

Remote Work Available

This company offers remote work opportunities. Team members are distributed across the U.S. and Canada.

Open Positions3

US- RemoteFull-TimeBiotechnologyPosted

Associate Director, Analytical Sciences and Attribute Characterization

Provide strategic and technical leadership for multidimensional biologics characterization.
Serve as subject matter expert (SME) in mAb and mAb-mAb combination product molecular characterization.
Contribute to analytical control strategies and regulatory content development.
Lead comparability and characterization activities at CDMOs.
Ensure analytical activities meet scientific, regulatory (FDA, EMA, ICH), and industry standards.
Develop characterization strategies in collaboration with analytical SMEs.
Partner with process (DS, DP, device) and regulatory teams.
Support ADQC activities, including method development and investigations.
Establish best practices for structure–function relationships, PTM analysis, and CQA assessment.

Artificial IntelligenceMachine Learning

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About Spyre Therapeutics

Spyre Therapeutics pioneers long-acting antibody therapies to transform treatment for inflammatory bowel disease (IBD) and other immune-mediated conditions. Your work here directly impacts patients suffering from chronic diseases. We focus on developing highly potent, selective, and patient-friendly antibody solutions. With over $560 million in funding, our public company is rapidly advancing a pipeline of investigational therapies. We recently dosed the first participants in Phase 1 trials for novel extended half-life anti-TL1A antibodies. Our innovative approaches aim for less frequent dosing, improving patient quality of life.

How We Work

You will join a primarily remote team, collaborating from anywhere in the United States. We emphasize frequent in-person meetings for strategic discussions and building strong relationships. Our interdisciplinary team fosters breakthrough discoveries and values courageous dissent. Decisions happen through collaborative input, not rigid hierarchy. We are committed to diversity, with women comprising 51% of our workforce as of February 2025. You will experience a culture that champions an ownership mindset and mutual commitment.

Why Join Us

Drive meaningful change in patient lives through novel antibody therapies.
Contribute broadly to our young, growing company and help shape its future.
Work in a remote-first environment with strong support for work-life integration.
Advance your career with dedicated professional development opportunities.
Receive competitive compensation, including equity grants and comprehensive benefits.

Benefits & Perks

Market competitive base salary and performance bonus structure
Equity grant opportunities for all employees
Comprehensive health, dental, and vision coverage
Unlimited Paid Time Off (PTO)
Two company-wide, one-week shutdowns annually
Stipends for ergonomic home office setups
Reimbursement for gym memberships
401(K) with company match
Life and disability insurance
Generous parental leave and fertility benefits