Lead/Staff Bioinformatician

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Requirements:

• Expert knowledge of bioinformatics tools for NGS including all aspects of sequencing QC and secondary analyses including variant calling.
• Experience with WES/WGS/targeted sequencing of tissue and cfDNA as well as  somatic variant calling on these data.
• Strong programming and scripting experience in Python, R and shell.
• Fluent in all aspects of exploratory data analysis and visualization for complex data sets and ability to distill observations to actionable recommendations.
• Deep understanding of NGS workflows from sample extraction to sequencing.
• Familiarity with cloud computing and workflow management tools such as SnakeMake, WDL or NextFlow.
• Ability to communicate effectively with wet lab groups and explain clearly technical bioinformatics concepts.
• Ability to work independently while managing multiple objectives and timelines
• Desire to work in a fast-paced environment with potential for high impact in a small team.

Responsibilities:

• Collaborate with bench scientists to design and analyze experiments to evaluate novel assay technologies, and provide independent interpretation and recommendations for assay optimization.
• Build rapid prototypes and pipelines for custom analysis by integrating data from multiple Natera products.
• Develop algorithms and tools as necessary to support development of new products, including contributions to the bioinformatics pipeline.
• Act as an internal technical consultant to other functional groups or their members by providing expert advice on bioinformatics methodology.
• Work closely with interdisciplinary teams including assay, engineering, biostats, commercial and lab operations to support the development of new products.