Centessa Pharmaceuticals, LLC

👥 11-50💰 $230,000,000 Post-IPO Equity about 1 year agoBiotechnology Biopharma Health Care

Posted 7 days ago

🧭 Full-Time

🔍 Pharmaceuticals

🔧 Requirements

5-10 years of formulation experience in various delivery forms (oral, subcutaneous, and intravenous) of small molecules supporting nonclinical and clinical formulation development.
Demonstrated understanding of technical aspects associated with the development and manufacture of poorly soluble (BCS Class II/IV) small molecule compounds for oral, subcutaneous, and intravenous delivery.
Familiarity with analytical characterization techniques such as HPLC/UPLC, and solid-state characterization tools, including XRPD, DSC, TGA, DVS, etc.
Strong organizational, analytical, and interpersonal skills.
Ability to work independently in a fast-paced dynamic environment with multiple projects.
Demonstrated ability to coordinate external development (CRO, CDMO, CMO) activities in the development of pharmaceutical products.
Knowledge of cGMP requirements for pharmaceutical products.
Strong decision-making and communication skills and resource management skills in a dynamic environment located across multiple geographies.

💡 Responsibilities

Manage and guide external vendors, such as Contract Research Organizations (CROs) and Contract Development and Manufacturing Organizations (CDMOs) to:
Execute physiochemical characterization and pre-formulation studies for New Chemical Entities (NCEs).
Design and develop nonclinical formulations of drug candidates (oral, subcutaneous, and intravenous) to ensure stability, bioavailability and effective drug delivery in animal models.
Design and oversee execution of nonclinical formulation stability and compatibility studies.
Support clinical formulation development of oral solid dosage forms, as needed.
Author and/or review and approve development and dose preparation protocols and reports.
Review formulation related sections of protocols and reports associated with Pharmacokinetic (PK), Pharmacodynamic (PD), and safety studies.
Represent CMC and provide nonclinical formulation, DS and DP stability, and supply guidance at internal and external cross functional team meetings.
Coordinate shipments in support of nonclinical and Clinical development supply requirements to various CDMO and CRO sites.
Assist in compiling formulation-related documentation for regulatory submissions (e.g., IND, CTA) to meet nonclinical development requirements.
Work closely and collaboratively with cross-functional CMC groups including discovery, nonclinical, clinical, project management, legal, sourcing, supply chain, quality and regulatory, as well as other CMC functions.

Posted 7 days ago

Posted 17 days ago

🧭 Full-Time

🔍 Biotech or life sciences

🔧 Requirements

8+ years of experience in finance or accounting, with a strong knowledge of GAAP.
Experience in the biotech or life sciences industry, with knowledge of industry-specific regulations and financial considerations.
Strong understanding internal control, audit methods, core business procedures, risks, and related exposure.
Excellent communication skills, both written and oral. Strong interpersonal skills, including discretion, tact, and courtesy.

💡 Responsibilities

Manage all aspects of SEC reporting, including the preparation and filing of 10-Q, 10-K, 8-K, Proxy Statements, and other required filings.
Provide technical accounting guidance on complex transactions, ensuring compliance with US GAAP, UK GAAP, IFRS and SEC requirements.
Lead the Sarbanes-Oxley (SOX) compliance process for 404(b), including the design, implementation, and testing of internal controls over financial reporting (ICFR).
Work closely with senior management, including the Controller, CFO, and other stakeholders, to ensure accurate financial reporting and compliance.
Coordinate with external auditors during quarterly reviews and annual audits.
Identify and implement process improvements in financial reporting and accounting.
Develop and assist with the preparation of financial materials for presentations to the Board of Directors and Audit Committee.

Posted 17 days ago

Posted about 2 months ago

📍 US

🧭 Full-Time

🔍 Pharmaceutical/Biotech R&D

🔧 Requirements

8+ years experience in pharmaceutical/biotech R&D with BS or 6+ years with MSc/MBA
4+ years as Project Manager or equivalent
Proven expertise in drug development processes
Expert in project management software

💡 Responsibilities

Project ManagementCross-functional Team LeadershipAnalytical SkillsBudgetingRisk Management

Posted about 2 months ago