Senior Scientist, Ex Vivo Systems and Assay Development

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Requirements:

• You have experience in ex vivo systems, particularly with advanced cultures like human cardiomyocytes and precision-cut lung slices.
• You possess expertise in mammalian cell culture and complex protocols, such as iPSC culture, slice cultures, and organoids.
• You are proficient in assay development, including RT-qPCR, cryosectioning, ELISAs, Western blotting, and histology.
• You have experience managing and collaborating on time-sensitive projects, guiding junior scientists, and improving throughput across departments.
• Experience in industry and familiarity with Lentiviruses/AAVs are pluses.

Responsibilities:

• Your primary mission will be to design, execute, and optimize ex vivo experiments that validate key targets from the screening platform.
• You will work with therapeutic leads across pulmonary fibrosis, heart failure, and MASH programs to set up and refine complex human tissue models.
• Your focus includes early validation or elimination of therapeutic targets and developing assays to evaluate safety, efficacy, and mechanisms of action.
• You will collaborate with disease biology heads to enhance workflow processes, establish SOPs, and streamline data-driven decision-making.
• You will manage experimental schedules and develop in vivo and ex vivo assays, ensuring validation or elimination of hits happens as early as possible.